Centre for Ayurbiology
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The Centre for Ayurbiology
focuses on bridging traditional ayurvedic wisdom with contemporary biomedical
science to advance health, wellness, and translational therapeutics.
The Centre for Ayurbiology is a multidisciplinary research initiative committed to advancing health and well-being by integrating the classical wisdom of Ayurveda with modern scientific innovation. The Centre focuses on unlocking the therapeutic potential of Ayurvedic formulations and diverse plant-based products through rigorous scientific validation, quality assessment, and safety evaluation. By applying modern analytical, molecular, and computational approaches, the Centre seeks to establish robust mechanistic insights, safety profiles, and quality benchmarks for Ayurvedic medicines. The Centre provides comprehensive quality analysis of Ayurvedic formulations using advanced instrumentation techniques, including liquid chromatography–mass spectrometry (LC–MS) for the identification and characterization of active principles. Detailed toxicity evaluation and safety assessment of Ayurvedic formulations form a key component of our research, ensuring their reliability, efficacy, and translational relevance. A major focus of the Centre is the systematic identification and profiling of bioactive compounds present in Ayurvedic formulations and raw herbal materials. In parallel, we are developing a comprehensive, curated database linking Ayurvedic formulations, medicinal plants, and their active principles, including detailed chemical information such as two-dimensional molecular structures. This resource aims to support research, innovation, and drug discovery efforts rooted in Ayurvedic knowledge.
Multi-Target Evaluation of Ayurvedic Formulations for Neurodegenerative Disorders
This thrust area focuses on the systematic evaluation of polyherbal and classical Ayurvedic formulations as multi-target therapeutics for complex chronic and neurodegenerative disorders, particularly Alzheimer’s disease. Special emphasis is placed on Medhya Rasayana formulations and their potential to enhance cognition, promote neuroprotection, modulate immunity, and support overall brain health. The research integrates experimental validation with advanced computational approaches to elucidate molecular mechanisms, identify active phytoconstituents, and establish evidence-based therapeutic strategies.
Combating Antimicrobial Resistance through Integrative Therapeutics
This core thrust area focuses on addressing antimicrobial resistance (AMR) by investigating the synergistic potential of Ayurvedic formulations in combination with conventional antibiotics against multi-drug resistant (MDR) bacterial infections. The objective is to enhance therapeutic efficacy, restore antibiotic sensitivity, and reduce antibiotic dosage requirements, thereby minimizing resistance development. Through integrated microbiological, pharmacological, and molecular approaches, this research aims to develop evidence-based adjunct therapies that offer sustainable solutions to the growing global AMR crisis.
Ayurgenomics and Personalized Medicine
This thrust area emphasizes the integration of Ayurvedic principles with modern genomic science to advance personalized medicine. The Centre undertakes dedicated research to elucidate the phenotypic and genotypic foundations of Prakriti through systematic clinical phenotyping, comprehensive biochemical profiling, and high-throughput genomic approaches, including whole-exome sequencing. By establishing robust phenotype–genotype correlations, this program aims to provide a scientific framework for individualized risk assessment, disease prediction, and precision therapeutic strategies grounded in Ayurvedic concepts.
Ongoing
Project Title: Investigating Phenotypic-genotypic correlations of Ayurveda Prakriti through a multidisciplinary approach
Budget: 7,000,000 INR
Funding Agency: Ministry of Ayush (2026-2029)
Principal Investigator: Dr. Dileep Vijayan, JCMR
Co-investigators: Dr. N V Sreevaths, Jubilee Ayurveda and Dr. Alex George, JCMR
Services
Scientific validation of Ayurvedic formulations
Identification and characterization of active principles from polyherbal and classical Ayurvedic formulations
Toxicity and safety evaluation of Ayurvedic formulations through in vitro and mechanistic screening assays
Bioactivity and efficacy assessment of Ayurvedic and plant-based formulations for neurological, metabolic, inflammatory, and infectious diseases
2020
1. Puthur Donata, Prasad Krishna, Varghese P R and Shadevan C D: Study On Effect Of Ayurvedic Treatment To Stabilize Creatinine Level And Control Progression Of Chronic Kidney Disease. International Ayurvedic Medical Journal; 4(4): April- May 2020, 2298-2302.
2019
1. Anumod Kakkassery A, Krishnan P, Varghese PR. Effective Ayurveda therapy to treat thyroid disorders. J Ayu Herb Med 2019; 5 (1): 10-12.