Dr. Remya Chandran
Dr. Remya Chandran
Scientist C, Laboratory for Computational and Structural Biology (LCSB)
remchandra@jmmc.ac.in
Dr. Remya Chandran currently serves as Scientist C at the Jubilee Centre for Medical Research, Thrissur, where she contributes to integrative strategies for the discovery of therapeutics targeting neurodegenerative and inflammatory disorders. Her research focuses on the identification of neuroprotective agents and the elucidation of their mechanisms of action in Alzheimer disease (AD), with particular expertise in multi-target drug design. She completed her Ph.D. at Kannur University, in collaboration with Dr. Omkumar (Former Scientist, RGCB, Trivandrum), where she designed and evaluated multifunctional tacrine-based compounds targeting cholinesterases, beta-secretase, and NMDA receptors through a combination of computational modeling, chemical synthesis, and in vitro and in vivo validation. During her postdoctoral research at JCMR under Dr. Dileep Vijayan, she investigated brain-rejuvenating rasayanas with potential to counteract AD-like pathologies. Her technical expertise includes mammalian and primary neuronal cell culture, immunocytochemistry, protein ligand interaction studies, animal behavioral studies, molecular dynamics simulations, virtual screening, and structure-based drug design, with additional training in protein purification, stem cell culture, and microbiome research. Her current research spans immunopharmacology, the gut–brain/microbiome–immune axis, and natural product inspired drug discovery.She focuses on the identification of TREM receptor modulators for inflammatory/neuroinflammatory disorders and on the development of small-molecule immune checkpoint inhibitors and COX2–PGE₂–EP pathway modulators to overcome antitumor immune evasion.
Citations: >550
h-index: 13
i10-index: 18
Google Scholar ID: https://scholar.google.com/citations?user=V4hm2q4AAAAJ&hl=en
Orcid ID: https://orcid.org/0000-0002-
- Computational Drug Discovery
- Immuno-pharmacology
- Gut-Immune-Brain Axis
- Neuropharmacology
- PhD - Life Science (2019), Dept of Biotechnology and Microbiology, Kannur University, Kerala
- M.Sc. Bioinformatics (2007), Sree Ramakrishna College of Arts and Science for Women, Coimbatore, Tamil Nadu
- Scientist C, Jubilee Centre for Medical Research, Thrissur, Kerala, Jul 2025 - Present
- Chief Ministers Nava Kerala Post Doctoral Fellow, Centre for Medical Research, Thrissur, Kerala, Jul 2023 - Jul 2025
- DBT Research Associate, Centre for Medical Research, Thrissur, Kerala, Mar 2022 - Jul 2023
- Asst Professor (contract), Kannur University, Kannur, Kerala, Feb 2021 - Feb 2022
- Guest lecturer, College of Agriculture, Vellayini, Trivandrum, May 2020- Sept 2020
- Project Fellow, Kannur University, Kannur - Aug 2016 to Feb 2018
- ICMR-Senior Research Fellow, Kannur University, Kannur - Mar 2013 to Mar 2016
- Ph.D Student, Kannur University, Kannur, Apr 2011 to Apr 2018
- Junior Research Fellow, University of Madras, Chennai, Tamil Nadu, Jul 2008 to May 2009
- DBT-supported Studentship, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Dec 2007 to Jun 2008
- Best oral presentation award in the Scientist category, 37th Kerala Science Congress held at Kerala Agricultural college, Thrissur, during 07-10, February 2025
- Best paper award. Jubilee Research Day held at Jubilee Centre for Medical Research, JMMC & RI, Kerala, India. June 2024
- Best paper award. Jubilee Research Day held at Jubilee Centre for Medical Research, JMMC & RI, Kerala, India. May 2023
- Prof. (Dr.) GN Ramachandran Memorial award for best poster. GNR centenary symposium for structural biology held at Dept. of Biotechnology, CUSAT, during 21-22, February 2023.
- Second prize for best poster. International conference on drug discovery held at BITS- Pilani, Goa, India, during 10-11, Nov, 2022
- Chief Ministers Nava Kerala Post Doctoral Fellowship (Kerala State Higher Education Council, Govt of Kerala). May 2022
- Research Associate (Indian Council of Medical Research). April 2022 (Not availed)
- Research Associate (Department of Biotechnology, Govt of India). February 2022
- Senior Research Fellowship (Indian Council of Medical Research). Mar. 2013.
- Senior Research Fellowship (Council of Scientific and Industrial Research). Mar. 2013 (Not availed).
- Best poster award. Bioinformatica Indica 2014. International Conference on Jan. 2014 held at Kerala University, India.
- UGC-NET-Lectureship. 2011.
- Best poster award. National seminar on Bioinformatics Application in Medical Sciences held at SRM University, Chennai, India. Mar. 2009.
- Award for excellence in studies. 4thrank in M.Sc. Bioinformatics from Bharathiar University, India. 2007.
Completed Projects
1. Area: Alzheimer's Disease Drug Discovery
Role: Post Doctoral Fellow
Funding Agency: Kerala State Higher Education Council, Govt of Kerala (2023-2025)
Project Title: Ayurvedic nootropics as countermines for Alzheimer's disease: Strategic thinking and reverse pharmacology assisted scientific expositions
Budget: INR - 2, 200,000/-
Mentor: Dr. Dileep Vijayan, Jubilee Centre for Medical Research, Kerala
2. Area: Alzheimer's Disease Drug Discovery
Role: Research Associate
Funding Agency: Department of Biotechnology, Govt of India (2022-2023)
Project Title: Targeting Alzheimer's disease with rationally designed polypharmacological prototypes
Budget : INR - 1,600,240/-
Mentor: Dr. Dileep Vijayan, Jubilee Centre for Medical Research, Kerala
3. Area: Alzheimer's Disease Drug Discovery
Role: Senior Research Fellow
Funding Agency: Indian Council for Medical Research, Govt of India (2013-2016)
Project Title: Identification and Designing of Mutipotent therapeutic agents against Alzheimer's Disease
Budget: INR - 904,800/-
Mentor: Dr. Jayadevi E Variyar, Kannur University, Kerala
2026
Aiswarya, N., Remya, C., Sajitha, K., Rajan, R., Vasudevan, D.M. and Dileep, K.V., 2026. Methyl eugenol as a multitarget-directed ligand for Alzheimer disease: A promising lead for drug design. ASPET Discovery, 2.
2025
Kumar, S. S., Remya, C., Krishnakumar, K., Maria, E., Dileep, K. V., & John, M. (2025). Modulation of COX-2, 5-LOX, and cytokine signalling by Carica papaya L. leaf cultivar Red Lady flavonoids in inflammation: In-vitro and in-silico insights. Natural Product Research, 17.
Sajitha, K., Rao, K. Y., Yesu, V. B., Chandran, R., Dileep, K. V., Narayana, V. V. P. C., et al. (2025). Design, synthesis, characterization and in vitro evaluation of anticholinesterase and antioxidant activities of thiazole piperazine sulphonamide hybrids. Chemistry & Biodiversity, 22(9), e202500567.
Aiswarya, N., Hima, S., Remya, C., Vasudevan, D. M., Dileep, K. V., & Francis, D. (2025). Molecular blueprints: Guiding drug discovery through protein structure analysis. Advances in Protein Chemistry and Structural Biology, 147, 37-99.
Hima, S., Aiswarya, N., Remya, C., Vasudevan, D. M., Dileep, K. V., & Dileep, F. (2025). Deciphering protein aggregation: Insights into morphology, factors, and diseases. Advances in Protein Chemistry and Structural Biology, 145, 23-71.
Babu, A., Remya, C., Sajith, A. M., Dileep, K. V., Kenchaiah, S., & Khade, A. (2025). The complex interplay between ligand strain, coulombic interactions, and binding site dynamics of two congeneric AChE inhibitors. Journal of Molecular Structure, 141479.
Paul, S., Chandran, R., Vijayan, D. K., Bhardwaj, J., Singh, P., Shetty, P., et al. (2025). Cdk5 inhibitor restores cognitive function and alleviates type-2 diabetes in mice. iScience.
Hima, S., Remya, C., Abhithaj, J., Arun, K. G., Sabu, A., Sajitha, K., et al. (2025). Structural and biophysical mechanisms of benzamidine-driven inhibition of human lysozyme aggregation. International Journal of Biological Macromolecules, 141-139.
2024
Kandrakonda, Y. R., Remya, C., Dileep, K. V., Shaik, J. B., Gajula, N. N., et al. (2024). Quinazolinone acrylamides as anti-Alzheimer agents: Modulation of amyloidogenic peptide assembly at the molecular level. ACS Chemical Neuroscience, 16, 1529-1538.
Rao, K. Y., Chandran, R., Dileep, K. V., Gorantla, S. C., Basha, S. J., et al. (2024). Quinazolinone hydrazine cyanoacetamide hybrids as multitarget-directed therapeutics against Alzheimers disease. ACS Chemical Neuroscience, 15(18), 3401-3420.
2023
Chandran, R., Dileep, K. V., Variyar, E. J., Omkumar, R. V., & Sadasivan, C. (2023). Unveiling the molecular basis of lobelines allosteric regulation of NMDAR: Insights from molecular modeling. Scientific Reports, 13, 22418.
Chandran, R., Dileep, K. V., Variyar, E. J., Omkumar, R. V., & Sadasivan, C. (2023). Lobeline: A multifunctional alkaloid modulating cholinergic and glutamatergic activities. IUBMB Life.
Hima, S., Chandran, R., Sadasivan, C., & Dileep, K. V. (2023). Carboxylic acid derivatives suppress the growth of Aspergillus flavus via inhibition of fungal alpha-amylase. Journal of Biomolecular Structure and Dynamics, 42(7), 3563-3567.
2022
Aiswarya, N., Chandran, R., Rema Shree, A. B., Sadasivan, C., & Dileep, K. V. (2022). Binding of rosmarinic acid, curcumin, and capsaicin with PLA2: A comparative study. Biochemical and Biophysical Research Communications, 626, 187-191.
2021
Chandran, R., & Dileep, K. V. (2021). Exploring the binding mode of PQ912 against secretory glutaminyl cyclase using conformational ensembles. Chemical Biology & Drug Design, 98, 850-856.
Chandran, R., Dileep, K. V., Reddy, E. K., Mantosh, K., et al. (2021). Neuroprotective derivatives of tacrine targeting NMDA receptor and acetylcholinesterase. Computational and Structural Biotechnology Journal, 19, 4517-4537.
Chandran, R., Dileep, K. V., Variyar, E. J., Zhang, K. Y. J., Omkumar, R. V., & Sadasivan, C. (2021). Chemical similarity-assisted search for acetylcholinesterase inhibitors. International Journal of Biological Macromolecules, 174, 466-476.
2020
Dileep, K. V., & Remya, C. (2020). Amyloid beta hypothesis in Alzheimers disease: Major culprits and therapeutic strategies. Current Drug Targets, 21, 148-166.
2019
Remya, C., Mantosh, K., Lakshmi, K., et al. (2019). Cellular calcium signaling in the aging brain. Chemical Neuroanatomy, 95, 95-114.
Dileep, K. V., Ashok, S., Remya, C., et al. (2019). Indole fragments for the design of lead molecules against pancreatitis. Journal of Biomolecular Structure and Dynamics.
2018
Dileep, K. V., Remya, C., Tintu, I., Mandal, P. K., et al. (2018). Crystal structure of phospholipase A2 complexed with 1-naphthaleneacetic acid. IUBMB Life, 70(10), 995-1001.
Dileep, K. V., Remya, C., & Nithiyanandan, K. (2018). Binding of acarbose to lysozyme: Structural and thermodynamic study. Journal of Biomolecular Structure and Dynamics, 36(13), 3354-3361.
2017
Reddy, E. K., Remya, C., Sajith, A. M., et al. (2017). Novel tacrine derivatives with improved acetylcholinesterase inhibition. European Journal of Medicinal Chemistry, 139, 367-377.
2016
Remya, C., Dileep, K. V., Tintu, I., & Sadasivan, C. (2016). In silico identification of nAChR agonists from Withania somnifera. Frontiers in Life Science, 9, 201-213.
Reddy, E. K., Remya, C., Sajith, A. M., et al. (2016). Functionalized dihydroazo pyrimidine derivatives as acetylcholinesterase inhibitors. RSC Advances, 6, 77431-77439.
