Dr. Alex George

Dr. Alex George

Dr. Alex George

Head and Scientist D
alexgeorge@jmmc.ac.in

Dr. Alex George is a translational scientist with over 15 years of experience in human genetics, cancer biology, and clinical research across academic medical centres and international collaborations. He currently serves as Scientist D at the Jubilee Centre for Medical Research, where he contributes to multidisciplinary programs integrating molecular biology, genomics, and clinical investigation. His expertise spans cytogenetics, molecular diagnostics, telomere biology, liquid biopsy, extracellular vesicle biology, and next-generation sequencing (NGS). Dr. George's research focuses on congenital anomalies, cancer progression, and complex multifactorial disorders, with an emphasis on translating molecular insights into clinical applications. He completed his postdoctoral fellowship at Canterbury Christ Church University, UK, as an ICMR-DHR International Fellow, and earned his PhD in Human/Medical Genetics from Vellore Institute of Technology.

  • Cancer Biology
  • Orofacial Clefts
  • occupational Health and Genotoxicity
  • Multi Omics
  • PhD - Specific focus on Human Genetics (2010-2014) , Vellore Institute of Technology, Vellore, Tamilnadu
  • M.Sc. Biomedical Genetics 2008-2010, Vellore Institute of Technology, Vellore, Tamilnadu
  • Scientist D- Jul 2022 - Present
  • Scientist C- Oct 2016 - Jun 2022
  • Scientist B- Oct 2014 - Oct 2016
  • ICMR-DHR International Fellowship (2019) - Specific focus on Cancer Biology and Extra Cellular Vesicle Research, Canterbury Christ Church University (CCCU), Kent, The United Kingdom
  • Student Research Project Scheme: Biological Sciences (Including Biotechnology- 2009)- Focus on Gene - environment interactions in ocular disease Sponsored by DBT and Tamilnadu State Council for Science and Technology during the academic year 2009-2010

Ongoing Projects

1. Area: MiRNA in Infertility 
Budget: INR - 5,106,000 (ICMR)
Role: Co-investigator

2. Area: Ayurveda-Prakruthi 
Budget: INR - 7,000,000 (AYUSH)
Role: Co- Investigator

Completed Projects

1. Area: Orofacial Clefts
Role: Principal Investigator
Funding Agency: Smile Train India (2021-2024)
Project Title: Epidemiological and Genetic Research among the Orofacial cleft patients from Central Kerala:
A hospital-based Case Control Study
Budget: INR - 7,860,000/-

2. Area: Psychiatry and State (biochemical) and Trait (genetic) markers in alcoholism Funding Agency: ICMR,
Role: Co- investigator (Trait Markers identification and Sequencing)
Funding Agency: ICMR, Govt. of India (2019-2021)
Project Title: Influence of demographic, clinical, genetic and pattern of management in maintaining long term abstinence among patients of alcohol use disorders who received treatment from De-addiction centres in Thrissur district: A prospective follow up study
Budget: INR - 5,300,000 /-

3. Area: SARS Cov2 Variants among PLHIV Dr. Alex George (Role _SarsCov-2 Sequencing)
Role-:Co- investigator ( SarsCov-2 Sequencing and Analysis)
Funding Agency: ICMR, Govt. of India (2022-2023)
Project Title: Effectiveness of Covid Vaccine and identification of SARS Cov2 Variants among PLHIV in Central Kerala:  An Ambi-directional Cohort Study
Budget: INR - 3,974,770/-
2025
  • Alappat RR, Sachith SK, Narayanan PV, George A. Major allelic variants in IRF6 and the association with Non-Syndromic orofacial Clefts: Insights from a Kerala-Based Case-Control study. Gene. 2025 Jul 5;955:149450.
  • Padinharayil H, Varghese J, Varghese PR, Wilson CM, George A. Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis. Proteomes. 2025 Apr 23;13(2):15.
  • Jyothish A, George A, Narayanan PV, Krishnamurthy RG. MSX1 Gene Polymorphisms in Patients with non-Syndromic Cleft lip and Palate: A Tertiary Care Centre Based Case-Control Study from Central Kerala. The Cleft Palate Craniofacial Journal. 2025 Mar;62(3):504-12.
  • Alappat RR, Sachith SK, Varghese PR, Narayanan PV, George A. Parental transmission effects of the IRF6 polymorphisms among Non-Syndromic Cleft Lip with or without cleft palate in Kerala case parent trios. Archives of Oral Biology. 2025 Feb 1;170:106134.
2024

  • Padinharayil H, George A. Small extracellular vesicles: multi-functional aspects in non- small cell lung carcinoma. Critical Reviews in Oncology/Hematology. 2024 Apr 3:104341. 
  • Padinharayil H, Varghese J, Wilson C, George A. Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management. LifeSciences. 2024 Feb 28:122542. 
2023
  • Kannampuzha S, Gopalakrishnan AV, Padinharayil H, Alappat RR, Anilkumar KV, George A, Dey A, Vellingiri B, Madhyastha H, Ganesan R, Ramesh T. Onco-Pathogen Mediated Cancer Progression and Associated Signaling Pathways in Cancer Development. Pathogens. 2023 May 28;12(6):770. 
  • Renu K, Mukherjee AG, Gopalakrishnan AV, Wanjari UR, Kannampuzha S, Murali R, Veeraraghavan VP, Vinayagam S, Paz-Montelongo S, George A, Vellingiri B. Protective effects of macromolecular polyphenols, metal (zinc, selenium, and copper)-Polyphenol complexes, and pectin in different organs with an emphasis on arsenic poisoning: A review. International Journal of Biological Macromolecules. 2023 Sep 5:126715. 
  • Anilkumar KV, Rema LP, John MC, John TV, George A. miRNAs in the prognosis of triple-negative breast cancer: A review. Life Sciences. 2023 Oct 17:122183. 
  • Thomas J, Rajmohan P, Jose P, Kannan R, Jose R, Uttumadathil Gopinathan U, Raphael L, Baiju NM, Krishna S, Attokaran T, Bency A T J, Venugopal A, Sheela S, Kallempadam A, Jose L, Innah SJ, Varghese PR, George A. Real-World Effectiveness of COVID-19 Vaccine and Identification of SARS-CoV-2 Variants among People Living with HIV on Highly Active Antiretroviral Therapy in Central Kerala of India-An Ambi- Directional Cohort Study. Viruses. 2023 Oct 30;15(11):2187. doi: 10.3390/v15112187. PMID: 38005865; PMCID: PMC10674822. 
  • Kannampuzha S, Murali R, Gopalakrishnan AV, Mukherjee AG, Wanjari UR, Namachivayam A, George A, Dey A, Vellingiri B. Novel biomolecules in targeted cancer therapy: A new approach towards precision medicine. Medical Oncology. 2023 Nov;40(11):1-5. 
  • Raj S, Varghese L, Narayanan PV, Raveendran SK, Varghese PR, George A. Identification of heterochromatic variations in nonsyndromic cleft lip and palate. Journal of Orofacial Sciences. 2023 Jan 1;15(1):55-60.
  • Padinharayil H, Rai V, George A. Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy. Cancers. 2023 Feb 8;15(4):1070. 
  • Mukherjee AG, Renu K, Gopalakrishnan AV, Veeraraghavan VP, Vinayagam S, Paz- Montelongo S, Dey A, Vellingiri B, George A, Madhyastha H, Ganesan R. Heavy Metal and Metalloid Contamination in Food and Emerging Technologies for Its Detection. Sustainability. 2023 Jan;15(2):1195. 
2022
  • Renu K, Mukherjee AG, Wanjari UR, Vinayagam S, Veeraraghavan VP, Vellingiri B, George A, Lagoa R, Sattu K, Dey A, Gopalakrishnan AV. Misuse of Cardiac Lipid upon Exposure to Toxic Trace Elements—A Focused Review. Molecules. 2022 Jan;27(17):5657. 
  • Renu, K.; Vinayagam, S.; Veeraraghavan, V.P.; Mukherjee, A.G.; Wanjari, U.R.; Prabakaran, D.S.; Ganesan, R.; Dey, A.; Vellingiri, B.; Kandasamy, S.; Ramanathan, G.; Doss C, G.P.; George, A.; Gopalakrishnan, A.V. Molecular Crosstalk between the Immunological Mechanism of the Tumor Microenvironment and Epithelial–Mesenchymal Transition in Oral Cancer. Vaccines 2022, 10, 1490. 
  • Padinharayil H, Varghese J, John M C, Rajanikant G K, Wilson C M, Al-Yozbaki M, Renu K, Dewanjee S, Sanyal R, Dey A, Mukherjee A G, Wanjari U R, Gopalakrishnan A V, George A. Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics. Genes and Disease 
  • Ramgir SS, Renu K, Vellingiri B, George A, Tirupapuliyur D, Thiagarajan P, Valsala Gopalakrishnanan A. Phytomedicinal therapeutics for male infertility: critical insights and scientific updates. Journal of natural medicines. 2022 Apr 4:1-28. 
  • Rai S, Badarinath AR, George A, Sitaraman S, Bronson SC, Anandt S, Babu KT, Moses A, Saraswathy R, Hande MP. Association of telomere length with diabetes mellitus and idiopathic dilated cardiomyopathy in a South Indian population: A pilot study. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2022 Feb 1;874:503439. 
2021
  • Renu K, Panda A, Vellingiri B, George A, Valsala Gopalakrishnan A. Arsenic: an emerging role in adipose tissue dysfunction and muscle toxicity. Toxin Reviews. 2021 Oct 20:1-0. 
  • Mukherjee, A.G., Wanjari, U.R., Chakraborty, R., Renu, K., Vellingiri, B., George, A., CR, S.R. and Gopalakrishnan, A.V., 2021. A review on modern and smart technologies for efficient waste disposal and management. Journal of Environmental Management, 297, p.113347. 
  • Belkozhayev, A.M., Al-Yozbaki, M., George, A., Sharipov, K.O., Byrne, L.J. and Wilson, C.M., 2021. Extracellular vesicles, stem cells and the role of miRNAs in neurodegeneration. Current Neuropharmacology. 
  • Renu, K., Chakraborty, R., Haritha, M., Rajeshwari, K., Famurewa, A.C., Madhyastha, H., Balachandar, V., George, A. and Abilash, V.G., 2021. Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) induced hepatotoxicity: review. Chemosphere, p.129735. 
2020
  • Wilkin PJ, Al-Yozbaki M, George A, Gupta GK, Wilson CM. The undiscovered potential of essential oils for treating SARS-CoV-2 (COVID-19). Current Pharmaceutical Design. 2020 Oct 15. (Q2,)
  • Al-Yozbaki M, Acha-Sagredo A, George A, Liloglou T, Wilson CM. Balancing neurotrophin pathway and sortilin function: Its role in human disease. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. 2020 Sep 18:188429. 
  • Woodman C, Vundu G, George A, Wilson CM. Applications, and strategies in nanodiagnosis and nanotherapy in lung cancer. Seminars in Cancer Biology 2020 Feb 20.
  • Krishna L, Sampson U, Annamala PT, Unni KM, Binukumar B, George A, Sreedharan R. Genomic Instability in Exfoliated Buccal Cells among Cement Warehouse Workers. The Journal of Occupational and Environmental Medicine. 2020 Jan;11(1):33. 
2019
  • Raveendran SK, Ramachandran L, Joseph L, Asokan AK, Raj S, George A, James J. A novel SRY gene mutation c. 266 A> T (p. E89V) in a 46, XY complete gonadal dysgenesis patient. Andrologia. 2019 Oct;51(9): e13377. 
  • George A, Venkatesan S, Ashok N, Saraswathy R, Hande MP. Assessment of genomic instability and proliferation index in cultured lymphocytes of patients with Down Syndrome, Congenital Anomalies and Aplastic Anaemia. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2018 Jun 8. 
2018
  • Vijayaraghavan D, Joseph C, George A. Clinical and Cytogenetic Analysis of a Baby with Vestigial Tail and Limb Defects. Journal of medical science and clinical jcmr. Volume 06 Issue 07 2018 July 
2017
  • Vidya PV, George A, Chitra KC. An in vitro study on the induction of micronuclei and other nuclear anomalies in peripheral blood lymphocyte culture by metal oxide 
Ms. Liji M J
Ms. Liji M J
Research Assistant
Ms. Rasheeda Hussain
Ms. Rasheeda Hussain
Research Scholar
Ms. Hafiza P
Ms. Hafiza P
Research Scholar