Methyl eugenol as a multitarget-directed ligand for Alzheimer disease: A promising lead for drug design

• Description :

  This study explores the therapeutic potential of phytochemicals from spices in managing Alzheimer\'s disease, a progressive condition marked by amyloid-β accumulation, oxidative stress, and neuroinflammation. Methyl eugenol emerged as a promising multi-target compound, showing strong binding affinity to monoamine oxidase B (MAO-B) and moderate inhibition of acetylcholinesterase, both key enzymes implicated in disease progression. In vitro assays further demonstrated neuroprotective effects against Aβ-, lipopolysaccharide-, and glutamate-induced toxicity in SH-SY5Y cells, indicating its ability to reduce oxidative damage, inflammation, and excitotoxicity. Overall, the findings highlight methyl eugenol as a potential multi-target-directed agent and reinforce the promise of phytochemicals in developing disease-modifying therapies for Alzheimer’s disease.